Safronika

Therapeutic indications and mechanism of action

So far, various effects of saffron consumption have been reported in clinical research, these include antidepressant, anticonvulsant, antiparkinsonian effects, improving memory and learning ability, anti-pain and inflammation, lowering blood pressure, improving blood flow in the eyes, improving performance. Retina, anti-tumor and anti-cancer effects, effect on heart diseases and blood vessel occlusion, improvement of symptoms and complications of diabetes and diabetic retinopathy, antioxidant and scavenger of free radicals.

• Depression
• Anxiety
• Alzheimer
• Attention Deficit Hyperactivity Disorder (ADHD)
• Multiple sclerosis (MS)

Depression:

• Dopamine and norepinephrine reabsorption inhibition
• Serotonergic effects
• Neuroendocrine regulation
• Neuroprotective effects

Anxiety:

• Interact in benzodiazepine binding site in the GABA receptor
• Effective antioxidant and anti-inflammatory properties

Clinical studies have shown that the saffron extract in Safronika can treat mild, moderate and severe depression with anxiety, similar to drugs such as Fluoxetine, Citalopram and Imipramine, and is equally effective. In addition, it does not have side effects such as dry mouth and drowsiness and confusion in Imipramine.

Alzheimer’s:

• It prevents the formation of soluble oligomers and the formation of fibrillar complexes
• Crocin is an effective factor in protecting the hippocampus
• Protects brain cells
• It modulates the accumulation of Aβ and tau proteins
• Reduces cognitive and memory disorders

Clinical studies have shown that the saffron extract in Safronika works in the treatment of Alzheimer’s like drugs such as donepezil and Memantine and has even better effects on the cognitive performance of patients.

ADHD:

• Improvement of hyperactivity
• Improving the quality of sleep, and creating a pleasant and long sleep
• Effective antioxidant and anti-inflammatory properties

Clinical studies have shown that the saffron extract found in Safronika works in the treatment of ADHD like drugs such as Ritalin and has even better effects on falling asleep and reducing hyperactivity.

Multiple Sclerosis (MS):

• Inhibition of leukocyte infiltration
• Inhibition of oxidative reactions

• Protective effect in autoimmune encephalomyelitis